![]() The actions of mature neurotrophins are mediated by the high affinity full-length Trk receptors, which signal through their intrinsic tyrosine kinase activity to promote growth. Neurotrophins bind two classes of membrane receptors, the tropomyosin receptor kinase (Trk) family of receptors and the p75 neurotrophin receptor (p75NTR) (for a review see Chao, 2003). Pro-neurotrophins can also influence developing and mature neural circuits, and may be released in a developmentally regulated manner ( Lee et al., 2001 Lu et al., 2005 Teng et al., 2005 Yang et al., 2009). They are initially synthesized as precursor proteins (pro-neurotrophins), which are processed intracellularly to be secreted mostly in a mature, biologically active form ( Mowla et al., 1999 Mowla et al., 2001 Matsumoto et al., 2008 for review see Lu et al., 2005). ![]() Neurotrophins are growth factors with crucial roles in the developing and mature nervous system.
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